Beilstein J. Org. Chem.2019,15, 1226–1235, doi:10.3762/bjoc.15.120
Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EQ, UK 10.3762/bjoc.15.120 Abstract We here explore how ball-mill-grinding frequency affects the kinetics of a disulfide exchange reaction. Our kinetic data show that the reaction progress is similar at all the frequencies studied (15–30 Hz
grinding; grinding frequency; kinetics; mechanism; mechanochemistry; Introduction
We describe here an unusual frequency-dependence in the induction period of a covalent reaction carried out using ball-millgrinding. We present a kinetic analysis indicating that this is due to the successive fracture of
crystals into smaller particles followed by the accumulation of energy in crystal defects. In recent years, manual and ball-millgrinding have become increasingly routine solid-state synthesis tools [1]. Generally referred to as mechanochemistry, these methods are more environmentally friendly and usually
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Graphical Abstract
Scheme 1:
Solid-state exchange reaction through ball-mill grinding under neat ball-mill-grinding conditions (...